This publication from the World Health Organization (WHO) is a guide on the integration of sexually transmitted infection (STI) services with pre-exposure prophylaxis (PrEP) for HIV prevention. Aimed at program managers and healthcare providers, it highlights the epidemiology of STIs and the high burden among individuals using PrEP. The document outlines the rationale for integrating STI services, detailing planning, implementation, human resources, costs, and evaluation of integrated services. It emphasizes improving STI detection, counseling, prevention, and treatment, and advocates for a syndromic approach in clinical settings. The guide serves as a comprehensive resource for enhancing healthcare delivery and addressing the dual challenges of HIV and STI management.