This World Health Organization report analyzes the severity of COVID-19 disease in hospitalized patients during the periods dominated by the Omicron and Delta variants of the SARS-CoV-2 virus. It uses anonymized data from patients in South Africa to assess clinical characteristics and outcomes. The study aims to understand differences in disease severity, which has implications for public health planning, resource allocation, and clinical management protocols. The report is intended for healthcare professionals, researchers, and policymakers involved in pandemic response efforts.