This book examines philosophical aspects of the future of man and humanity, focusing on questioning what is and what constitutes “being human” in the face of scientific and technological developments and possible coexistence with machines and artificial intelligence. In this sense, the contribution of these authors is the establishment of a new discipline that analyses our technological future, which may be populated by enhanced cyborgs, avatars, and autonomous robots. This scientific-technological future brings about practically inconceivable social and philosophical consequences. Thus, this book answers the questions: What are the ethical and ontological issues and assumptions we make about humans and how will these change with time? Moreover, how should we think of human existence in this new and emerging world?