Hotshot detective Jack Conrad is investigating a string of disappearances linked to Glow, a rampant street drug that causes the eyes to exude an eerie luminescence. As he nears a breakthrough in the case, his wife and daughter are brutally murdered. His world shattered, Jack becomes a Glow addict himself. By night he scours the city's dangerous underworld for his family's killer, a search that soon uncovers Glow's extraterrestrial origins. With the help of a mysterious young stripper and a ragtag group of criminals, Jack races against time to thwart Glow's chilling ultimate purpose, which threatens all humanity.