This book constitutes the refereed proceedings of the XXIInd International Conference on AIxIA 2023 – Advances in Artificial Intelligence, AIxIA 2023, held in Rome, Italy, during November 6–10, 2023. The 33 full papers included in this book were carefully reviewed and selected from 53 submissions. They were organized in topical sections as follows: Argumentation and Logic Programming, Natural Language Processing, Machine Learning, Hybrid AI and Applications of AI.