Dr. Gillespie has scoured the nation for the perfect assistant he can trust to carry on his heroic work. When he finds Dr. James Kildare, he is nearly convinced he has the right person. To be absolutely sure, he sends the young doctor to the slums of New York to prove himself. On his first case, young Dr. Kildare not only defies Dr. Gillespie, but endangers himself and faces disgrace, all for a lovely girl.