"Blazing Guns on the Santa Fe Trail" introduces Clint Carrigan, a daring and resourceful teamster who works freight wagons on the Santa Fe Trail in the 1840s. Clint carries the big caliber Hawken Rifle and the new Patterson Colt five shot repeating revolver and is ready to face the dangers on the thousand mile trail between Independence Missouri and the western town of Santa Fe. Clint has caught the eye of a beautiful local girl named Maria, but he must complete another round trip delivery to the states and back before he can protect the lovely lady from an arrogant caballero and former beau named Estevan. Clint is challenged by former teamster partner Jake Owen whose changed loyalty and mis-deeds pose a threat the safety of the wagons, merchandise and lives of fellow teamsters. Clint's brother Connor Carrigan joins the Army of the Texas Republic and participates in the ill-fated Texas Santa Fe Expedition. The soldiers become prisoners of the Governor of Nuevo Mexico. Will the brothers re-unite as these events merge and their stories unfold? Can Clint survive the dangers of the Santa Fe Trail and overcome the greed of partner Jake? Will he be able to rescue brother Connor from incarceration at the Governor's palace? Will Clint have to confront Estevan to protect the honor of the lovely Maria?