This book, now in its second edition, provides an in-depth analysis of the challenges faced by micro, small, and medium enterprises (MSMEs) in Sampit City, along with updated solutions and steps for their development and growth. Authored by Rani Evelin Oktaviyanti and Rhegy Septiawan, a management student at Universitas Darwan Ali, this edition incorporates the latest research findings and insights gained from extensive study conducted as part of her Merdeka Belajar Kampus Merdeka (MBKM) program, under the guidance of her academic advisor, Mr. Andy Ismail. Divided into several chapters, the book covers various aspects of MSMEs in Sampit City, including their historical background, development trajectory, prevalent business models, potential growth avenues, and the persistent challenges concerning capital, management, and technology. Moreover, it offers practical solutions and actionable tips for overcoming these obstacles, featuring updated information on governmental support initiatives, success strategies tailored for Sampit City's business landscape, and effective marketing and sales methodologies. In its conclusion, the book succinctly summarizes its key findings and underscores the pivotal role of MSMEs in driving the economic prosperity of Sampit City. With its enriched content, the second edition serves as an invaluable resource for entrepreneurs, business owners, policymakers, and scholars keen on understanding the evolving dynamics of MSMEs in Sampit City, as well as for those interested in the broader context of economic development in Indonesia.