It is indeed a moment of pleasure for me to put forward a revised version of “A Practical Handbook of Rasashastra & Bhaishajya Kalpana” before the student fraternity of Ayurveda. Recently, the National Commission of Indian System of Medicine (NCISM) has made notable changes to the existing curriculum of Rasashastra and Bhaishajya Kalpana, making it more relevant, practical, and contemporary. As per the revised regulation, the nomenclature of the subject is now Ayurvediya Aushadhi Nirmana Vigyana as paper I and Ayurvediya Aushadhi Prayoga Vigyana as paper II for Second Professional BAMS course. In this revision, NCISM has tried its best to take Rasashastra and Bhaishajya Kalpana teaching beyond the classroom's four walls and connect it with present global needs. For effective content delivery to create interest in the subject, it becomes evident to teach Rasashastra & Bhaishajya Kalpana with practical demonstrations. To facilitate proficiency in pharmaceutical preparation and its application in clinical practice, more non-lecture classes are allotted. Teaching methodology guidelines are provided which shall be followed while teaching, to make baseline uniformity in the process of learning. Activity-based learning will enable the internalization of the concepts and will build a strong platform while learning other subjects of Ayurved. Thus, the New curriculum provides a thorough multidimensional knowledge in the cognitive domain, hands-on training of pharmaceutical processing in the Psychomotor domain, and ethical attitudes toward drug development in an affective domain. Rasashastra and Bhaishajya Kalpana, an Ayurvedic Pharmaceutics, deal with formulations. The book intends to impart the knowledge of principles related to Rasashastra and Bhaishajya Kalpana and to explain the methods of preparation of various Ayurvedic dosage forms to the students as Ayurveda is recognized with its medicines and the popularity of Ayurveda is based on good quality of medicines. Rasashastra mainly deals with the Mercurial preparations. Mercury, metals, and minerals produce some toxic effects on organs of the body and tissues on internal use is not a new observation by modern scientists only. The ancient scholars of Ayurveda have given very much due importance to this aspect and have taken care of this point effectively by involving common as well as specific methods for their Shodhana processes which are elaborately described in this book in Prakriya paribhasha section. Shodhana and Marana process of Rasashastra, play a very important role in making the ayurvedic, metallic and mineral preparations free of toxicity and making these highly absorbable into the system as compared to the modern chemical methods. It has been proved by toxicity studies conducted at various research centers in the country. Hence it is the responsibility of every budding Ayurveda graduate to take the initiative, to show a keen interest in the preparations and to propagate the knowledge of this branch of pharmaceutics. Bhaishajya Kalpana mainly deals with the preparations of plant drugs. Though the number of formulations is mentioned in Brihatrayee and other Rasa texts, the description of their method of preparation is found in scattered form. Despite good texts on Rasashastra and Bhaishajya Kalpana no complete text in English on Rasashastra and Bhaishajya Kalpana practicals is available. This creates an absence of contentment among the teachers and students. Keeping given the difficulties faced by the students the book is designed according to the sequence of the new curriculum framed by NCISM. The work is divided into Ten parts. 1. Paribhasha concept based practicals 2. Panchavidha Kashaya Kalpana and their Upkalpana Practicals 3. Rasa Dravya Aushadhi Nirmana Practicals 4. Bheshaja Kalpana Practicals– I 5. Bheshaja Kalpana Practicals– II 6. Dosage Forms & Self- care Products Practicals 7. Quality Control Practicals 8. Field Visit/Study Tour 9. Hospital IPD Practical 10. Drug Dispensing Practical The silent features of the book can be highlighted as · The book is written in a simple and lucid manner explaining each preparation step by step. · Reference is given for each practical. · Precautions are given as safety measures. · Observations are given to understand the organoleptic characters of each formulation. · Special notes and comments are added whenever necessary. · Additional examples are enlisted with their reference, dose and uses. . Research updates conducted all over India are quoted on that particular preparation. The aim is to boost the confidence about that formulation as well as to create interest in research since the undergraduate level. For some formulations, different texts have described different methods of preparation. Hence the attempt is made to describe the simplest one. I hope that this book shall serve the purpose of a ready reckoner and meet the academic needs of undergraduate and postgraduate students of Ayurveda during their course of study. I hope this book shall serve as a useful tool to meet the requirements of the practicing physician and as a reference guide for the pharmaceutical industry. I convey my deep sence of gratitude to the Trusty of our university Hon'ble Sagarji Meghe, for giving me an opportunity to serve in their institution. I am thankful to all my departmental colleagues, friends, beloved PG students who inspired me to start and accomplishment of this work. My love and respect are with my spouse Dr. Renu, Children Dr. Gunjan and Nandan, Parents for their unconditional support. At last, I highly obliged to publisher for undertaking the publication of this work.