This is the proceedings of the 15th International Conference on Knowledge, Information and Creativity Support Systems, which aims to facilitate technology and knowledge exchange between International researchers/scholars in the field of knowledge science, information systems, and system science and creativity support systems intensively in November 2020. The conference covered a broad range of research topics in the fields of knowledge engineering and science, information technology, creativity support systems and complex system modeling.The conference has been an important event and has attracted many scientists, engineers and researchers from academia, government laboratories, and industry internationally. The proceedings include all of the accepted papers and outline of the excellent invited talks.