This book enables readers to develop a multidisciplinary understanding of natural, human-made, and coupled human-natural systems. The authors explore the structure, function, and dynamic mechanisms of various systems, both natural and human-made, as well as analyze their reciprocal interactions under the concept of “coupled human-natural systems.” The chapters challenge traditional planning and management assumptions and strategies for natural resources, human-altered systems, and the environment. Acknowledging the critical role of effective regulations, policies, and governance structures, the authors analyze advanced research and practices on policy design for managing natural, human-made, and coupled human-natural systems. They conduct impact evaluation and integrative ecosystems assessment, as well as discuss policy interventions and decision-making strategies. They acknowledge the localization of policy design, considering regional and global dynamics that shape responses of local human-made and coupled human-natural systems. A special collection of chapters analyzes legal foundations for sustainable development and strong institution. The authors explore models from both natural and social sciences to obtain and present significant research results. The book is a dispensable source of sustainability research and practice in human-made, natural, and coupled human-natural systems. It is for the scholars, practitioners, and advanced graduate students interested in systems theories, methodologies, and applications.