A Death Most Quiet details the riveting criminal investigations of Captain Edward McCuen as he leads the NYPD's Crime Scene Unit on a relentless pursuit of three elusive serial killers. With the help of his team, McCuen follows a trail of mysterious murders alongside an eccentric mathematician named Anselm Winterbottom, who McCuen has leveraged as an investigatory consultant. The two men have a turbulent friendship, and it soon becomes clear that Winterbottom's ultimate aim is far from altruistic. While their alliance is tested, a crime reporter seeks to uncover the true identity of the man who is helping McCuen. As the hunters become the hunted, this three-part crime thriller delves into the dark corners of human nature, murder, and madness, staged amidst the landmarks of New York City, and the cultural treasures of the Metropolitan Museum of Art.