Doctor Griffin is about to give Larry Talbot his final dose of Monocaine B, which will prevent Talbot from turning into the Wolf Man. Dracula, along with his son, our daughter and the Frankenstein Monster, wants to get his hands on the Monocaine B because it will turn him invisible. Doctor Van Helsing brings in a team to help Griffin fight off Dracula and his brood. Among them is Dr. Allenby, the She Wolf of London. Doctor Griffin's son Jeremy is expecting a visit from his fiancée, Michaela Jekyll, daughter of Dr. Henry Jekyll. The stage is set for an epic monster mash tribute to the classic Universal Monster movies of the 1930s and 1940s.