The Greater Mekong Subregion (GMS) countries share common challenges and issues that prevent women from fully benefiting from economic opportunities. Many of these challenges have been further exacerbated by the COVID-19 pandemic. The GMS Gender Strategy outlines a regional approach for advancing gender equality and women’s empowerment in the subregion. It identifies strategic directions and key entry points to mainstream gender across all operational areas of the GMS Economic Cooperation Program. The strategy adds value to the GMS Program Strategic Framework 2030 and is also designed to complement national initiatives of the six GMS countries to bolster gender equality.