This proceedings volume features a selection of peer-reviewed papers presented at the 6th AMMCS-International Conference on Applied Mathematics, Modeling, and Computational Science, held in Waterloo, Canada, from August 14–18, 2023. The papers delve into topics where mathematical modeling and applications play a pivotal role, including computational models in physics and chemistry, statistical models in life science, analysis in science and engineering, and finance and social science methods, among others. Since 2011, the AMMCS conference series has provided a unique platform for technical discussions and the exchange of ideas in all areas related to mathematical, statistical, and computational sciences, modeling, and simulation. Esteemed researchers, industrialists, engineers, and students have presented their latest research and engaged with experts in the field, fostering interdisciplinary collaborations that address the challenges of modern science, technology, and society. This book is a valuable resource for academics and practitioners who are interested in the latest developments in these fields.