This book constitutes the refereed proceedings of the 16th International Conference on Blended Learning, ICBL 2023, held in Hong Kong, China, on July 17-20, 2023. The 24 papers presented in this volume were carefully reviewed and selected from 57 submissions. The papers are organized in topical sections named: smart classroom and digital literacy; online and distant learning; content and pedagogy development for blended learning; gamification and interactive learning environment; learning analytics and big data in education.