Living conditions in industrialized countries have led to a significant increase in life expectancy in recent decades. Likewise, the proportion of chronic diseases is growing. This includes cardiovascular diseases, chronic pain, inflammatory bowel diseases, and cancer. Unfavorable lifestyle factors, such as accumulative stress, lack of exercise, and poor nutrition, compounded by a persistent imbalance between exertion and recovery, lead to the manifestation and chronification of disease. A fundamental awareness of the connection between our mind, emotions, lifestyle, and health has grown. Understanding of body and mind interaction is increasing. The high clinical relevance is also supported and confirmed by evidence. Out of this field of research, mind-body medicine (MBM) has developed. MBM targets the interplay of body, mind, emotions, and behavior extending to the regulation of vegetative physiological signaling pathways.