Kanako is excited to be transferring into a new all-girl mission school. She's looking for her ideal yuri partner. When she meets Mariya Shidou she thinks she's found the one. But wait! Mariya is a cross-dressing sadistic boy and now Kanako is forced to keep his secret! But that's not all. To complicate things she's drawing the attention of the most popular girl in school and, at the same time, catching the wrath of all the other girls. Will Kanako ever find the cute girl of her dreams? Or will she die of sexual-frustration nosebleeds? Love is a complicated affair for Kanako and the girls of Maria Holic.