Drugs in Context is an independent, peer reviewed and practice orientated review of all the significant data on a specific drug, placed in the context of the disease and clinical practice setting. Vardenafil Editorial: It is critical that primary healthcare practitioners overcome their inhibitions and question their patients about their sex lives, particularly in the presence of common predisposing factors, including cardiovascular disease, hypertension, diabetes, depression and a variety of medications. Disease Overview: Oral therapy is considered by the World Health Organization and other country-specific guidelines to be a first-line approach in the treatment of ED. Drug Review: Vardenafil is a well-tolerated agent that provides significant response in terms of erectile function and also appears to improve general sexual function and sex-life satisfaction, regardless of age, or the origin or baseline severity of ED. Improving Practice: With this expanding global prevalence of ED, coupled with a growing awareness of the condition among physicians and patients alike, the management of the condition has become firmly routed in primary care.