Little Baby Imagination is about a brother-and-sister team who endeavor to better not just their lives, but also the lives of friends and family members with the power of imagination. Nemo and Niyah decide to change the past and the future by closing their eyes and imagining that things are the way they would like them to be. Nemo and Niyah encounter a grumpy and sad Mr. Niceman while riding the school bus. The duo decides not to accept this image of Mr. Niceman; through imagination they change the image and behavior of Mr. Niceman.