Building on the knowledge of risks, vulnerabilities, and safety measures associated with cyber-physical systems, this book focuses on adapting artificial intelligence (AI) techniques to smart cyber-physical systems application development. The future is going to see cyber-physical systems in almost every aspect of life, so a book that focuses on shedding light on the design, development, and security aspects of cyber-physical systems in more crucial domains such as defense, healthcare, biomedical, smart city applications, is needed. Integrating AI Techniques into the Design and Development of Smart Cyber-Physical Systems: Defense, Biomedical, Infrastructure, and Transportation offers an introductory exploration of the fundamental theories and concepts of AI and machine learning (ML) that are utilized in the building of dependable cyber-physical systems. It brings the ideas of advanced design and development and empowered security measures to cyber-physical systems. By focusing on the application of AI in cyber-physical systems design as well as security aspects, an improvement in reliability and advancements can be explored. Also included are the latest findings and advancements as well as case studies and illustrative examples on the design and development of smart cyber-physical systems. This resource is highly valuable for those employed in educational institutions, research laboratories, enterprises, and government agencies, as well as for students seeking novel ideas in the realm of smart cyber-physical systems design.