Borderlands are complex spaces that can involve military, religious, economic, political, and cultural interactions—all of which may vary by region and over time. John W. I. Lee and Michael North bring together interdisciplinary scholars to analyze a wide range of border issues and to encourage a nuanced dialogue addressing the concepts and processes of borderlands. Gathering the voices of a diverse range of international scholars, Globalizing Borderlands Studies in Europe and North America presents case studies from ancient to modern times, highlighting topics ranging from religious conflicts to medical frontiers to petty trade. Spanning geographical regions of Europe, the Baltics, North Africa, the American West, and Mexico, these essays shed new light on the complex processes of boundary construction, maintenance, and crossing, as well as on the importance of economic, political, social, ethnic, and religious interactions in the borderlands. Globalizing Borderlands Studies in Europe and North America not only forges links between past and present scholarship but also paves the way for new models and approaches in future borderlands research.