Natural and engineered slopes are widely distributed worldwide, including mountain slopes, highway slopes, mine slopes, reservoir dams, etc. These slopes could become unstable due to natural factors or human activities, causing catastrophic loss of life and infrastructure destruction. Therefore, these slopes require constant monitoring to provide early warning and enable mitigation. Advanced monitoring equipment, information technology, and multidisciplinary interaction theories have created new opportunities and challenges in this discipline. Recently, advanced monitoring devices, information technologies, and multidisciplinary intersection theories have contributed to the monitoring, early warning and mitigation of natural and engineered slopes. However, effective and efficient monitoring, precise early warning, low-cost and low-time-consuming remediation, and reliable risk assessment remain obstacles. This Research Topic aims to present the most recent innovative advancements and state-of-the-art natural and engineered slope monitoring, early warning, mitigation, and risk assessment.