When a Boeing 777 lands at JFK International Airport and goes dark on the runway, the Center for Disease Control, fearing a terrorist attack, calls in Dr. Ephraim Goodweather and his team of expert biological-threat first responders. Only an elderly pawnbroker from Spanish Harlem suspects a darker purpose behind the event - an ancient threat intent on covering mankind in darkness. In one week, Manhattan will be gone. In one month, the country. In two months - the world.