Mei, Cole, and the rest of the crew of SpiritScouts are filming the famously haunted campground Camp Moonlit Smiles when they encounter demonic activities. Mei and Cole run away and are shocked when they are rescued by cryptids including their Sasquatch leader Big Joe, Chupa the Chupacabra and Saxon the Mothman. Cryptid creatures that were once thought evil are in fact good forces fighting against demonic forces. This marks the beginning of countless adventures for the American Cryptids in their mission to rid their Earth of demons.