To begin: The information reported herein was virtually unknown with the first edition of the book over ten years ago. However, much of it today, piecemeal, is all over the web. Still, nowhere does it come with the depth reported herein. The science herein is reader based and that of personal experiences over the past years. The earlier editions of It's the Liver Stupid, have been well received around the world, but this 4th edition carries a new level MSM/ DMSO information that is simply not available elsewhere, With this update, you are told not only that it works (from reports), but now the basis. The Author receives emails from readers daily who have cured themselves, not only of the joint and arthritis problems that the 1st edition set out to teach, but now we have reports of cures that no one expected, from the big three: cancer, type II diabetes, heart disease, but also a slew of conditions that the Author did not even know existed ten years ago. Once you understand the underlying reason, that is, the supercharging of the mitochondria and the profound effects on the basic methylation cycles, you can see why this is the most powerful health measure that you can take to extend your life and upgrade your level of health. Interestingly, the healing effects can be much faster than we ever considered before also. Before, I was talking months and reports are that they can occur in days and weeks. With this update, the emphasis is even more on the self-healing and the spiritual effects on wellness. While this is not the final update, obviously, and, likely, this will always be an ongoing pursuit, it is a leap forward with lots of editing and new information added,