We proudly present the proceedings of 6th International Conference on Social and Political Enquiries 2021 (ICISPE 2021) with the main theme The Politics of Pandemics: Governing Social and Communal Resilience in Times of Crises. It focuses on the relation of policy and global network, regional integration, pandemics regulation, human security, and local government. These issues are important today, not only globally, but also Indonesia nationally to the local level. There are several important issues relating to this, both institutionally and the relationships between individuals and groups in supporting the agenda in managing the pandemics. More than 130 manuscripts were presented at this conference; around 60 of which are selected to be published in proceedings. We hope by this conference, discussions on the importance of sustainable development will increasingly become an important concern together and bring better response from the government and social relations for development.